Drug Discovery Center
Genome Research Institute
University of Cincinnati
2180 East Galbraith Rd
Cincinnati, OH 45237
ruben.papoian@uc.edu
Tel. (513) 558-0516

tel. 513-558-0516
ruben.papoian@uc.edu

Email Ruben

Publications

Ruben Papoian obtained his Ph.D. in Experimental Pathology from the University of California, San Francisco. His early research focused on autoimmune diseases, T-cell activation and immunological tolerance. Over the past 20 years he has worked in the pharmaceutical industry primarily, in Switzerland, with Sandoz AG, Serono SA and Novartis AG. His main areas of research were related to target identification and drug discovery in a number of therapeutic areas. Ruben has served a Laboratory Head, Dept. Head, Project Leader, Project Coordinator and Program Director. Ruben moved from Novartis, Basel, to the Genome Research Institute, University of Cincinnati in July 2005 as Research Professor and Director, Drug Discovery. His major goal is to build a first class drug discovery operation with assay development, HTS screening, hit identification, lead optimization culminating in drug candidate selection.


Publications

1:

Papoian R, Scherer A, Saulnier M, Staedtler F, Cordier A, Legay F, Maurer G, Staeheli J, Vonderscher J, Chibout SD VeloceGenomics: an accelerated in vivo drug discovery approach to rapidly predict the biologic, drug-like activity of compounds, proteins, or genes. Pharm Res. 2005 Oct;22(10):1597-613. PMID: 16086225 [PubMed - indexed for MEDLINE]

2:	Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW Microarray gene expression profiling of chronic active and inactive lesions in multiple sclerosis. Clin Neurol Neurosurg. 2004 Jun;106(3):223-9. PMID: 15177772 [PubMed - indexed for MEDLINE]

3:

Selvaraju R, Bernasconi L, Losberger C, Graber P, Kadi L, Avellana-Adalid V, Picard-Riera N, Van Evercooren AB, Cirillo R, Kosco-Vilbois M, Feger G, Papoian R, Boschert U Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro. Mol Cell Neurosci. 2004 Apr;25(4):707-21. PMID: 15080898 [PubMed - indexed for MEDLINE]

4:

Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda. Eur J Dermatol. ;13(6):560-70. PMID: 14721776 [PubMed - indexed for MEDLINE]

5:	Mycko MP, Papoian R, Boschert U, Raine CS, Selmaj KW cDNA microarray analysis in multiple sclerosis lesions: detection of genes associated with disease activity. Brain. 2003 May;126(Pt 5):1048-57. PMID: 12690045 [PubMed - indexed for MEDLINE]

6:	Ghersa P, Gelati M, Colinge J, Feger G, Power C, Ghersa P, Gelati M, Colinge J, Feger G, Power C, Papoian R, Salmaggi A MIG--differential gene expression in mouse brain endothelial cells. Neuroreport. 2002 Jan;13(1):9-14. PMID: 11924901 [PubMed - indexed for MEDLINE]

7:

Di Marco R, Khademi M, Wallstrom E, Iacobaeus E, Salvaggio A, Caracappa S, Papoian R, Nicoletti F, Olsson T Curative effects of recombinant human Interleukin-6 in DA rats with protracted relapsing experimental allergic encephalomyelitis. J Neuroimmunol. 2001 Jun;116(2):168-77. PMID: 11438171 [PubMed - indexed for MEDLINE]

8:	D'Antonio M, Martelli F, Peano S, Papoian R, Borrelli F Ability of recombinant human TNF binding protein-1 (r-hTBP-1) to inhibit the development of experimentally-induced endometriosis in rats. J Reprod Immunol. ;48(2):81-98. PMID: 11011074 [PubMed - indexed for MEDLINE]

9:	Boe A, Baiocchi M, Carbonatto M, Papoian R, Serlupi-Crescenzi O Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis. Cytokine. 1999 Dec;11(12):1057-64. PMID: 10623431 [PubMed - indexed for MEDLINE]

10:	D'Antonio M, Borrelli F, Datola A, Bucci R, Mascia M, Polletta P, Piscitelli D, Papoian R Biological characterization of recombinant human follicle stimulating hormone isoforms. Hum Reprod. 1999 May;14(5):1160-7. PMID: 10325254 [PubMed - indexed for MEDLINE]

11:	Giudice E, Crisci C, Eshkol A, Papoian R Composition of commercial gonadotrophin preparations extracted from human post-menopausal urine: characterization of non-gonadotrophin proteins. Hum Reprod. 1994 Dec;9(12):2291-9. PMID: 7714147 [PubMed - indexed for MEDLINE]

12:	Knopf HP, Duffy F, Papoian R A time-resolved fluoroimmunoassay for recombinant human interleukin-3. Ann Clin Biochem. 1993 Jan;30 ( Pt 1)():69-71. PMID: 8434869 [PubMed - indexed for MEDLINE]

13:

Valent P, Sillaber KC, Scherrer R, Geissler K, Kier P, Kalhs P, Kundi M, Papoian R, Bettelheim P, Hinterberger W Detection of circulating endogenous interleukin-3 in extensive chronic graft-versus-host disease. Bone Marrow Transplant. 1992 May;9(5):331-6. PMID: 1617317 [PubMed - indexed for MEDLINE]

14:	Papoian R Non-specific immunoglobulin interactions may lead to false-positive results in assays for human anti-mouse monoclonal antibodies (HAMA). J Immunoassay. 1992 ;13(2):289-96. PMID: 1430244 [PubMed - indexed for MEDLINE]

15:	Papoian R, Duffy F, Sanner M, Wilt E A sensitive ELISA for measuring recombinant human interleukin-3 in human plasma or serum. J Immunol Methods. 1991 Dec;145(1-2):161-5. PMID: 1765647 [PubMed - indexed for MEDLINE]

16:	Knopf HP, Papoian R Preparation of europium-streptavidin in a time-resolved fluoroimmunoassay for interleukin-3. J Immunol Methods. 1991 Apr;138(2):233-6. PMID: 2033276 [PubMed - indexed for MEDLINE]

17:	Senn HP, Papoian R Mitogenic effect of anti-Friend leukemia virus antiserum on T cells. Eur J Immunol. 1983 Oct;13(10):824-30. PMID: 6605858 [PubMed - indexed for MEDLINE]

18:	Papoian R, Talal N Ability of NZW but not NZB antigen-presenting cells to support T cell proliferative response to DNA methylated albumin. J Immunol. 1980 Feb;124(2):515-9. PMID: 6965382 [PubMed - indexed for MEDLINE]

19:	Papoian R, Roubinian JR, Dauphinée MJ, Talal N The New Zealand mouse as a model for the therapy of human SLE: immunomodulation of murine lupus by sex hormones and cyclophosphamide. Agents Actions Suppl. 1980 ;7():41-5. PMID: 6941685 [PubMed - indexed for MEDLINE]

20:	Roubinian JR, Papoian R, Pillarisetty R, Sawada S, Talal N Immunological regulation of spontaneous antibodies to DNA and RNA. III. Early effects of neonatal thymectomy and splenectomy. Immunology. 1977 Sep;33(3):399-406. PMID: 908585 [PubMed - indexed for MEDLINE]

21:	Roubinian JR, Papoian R, Talal N Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066-70. PMID: 864003 [PubMed - indexed for MEDLINE]

22:	Roubinian JR, Papoian R, Talal N Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW F1 mice. J Immunol. 1977 May;118(5):1524-9. PMID: 870559 [PubMed - indexed for MEDLINE]

23:	Papoian R, Pillarisetty R, Talal N Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice. Immunology. 1977 Jan;32(1):75-9. PMID: 300353 [PubMed - indexed for MEDLINE]

24:	Talal N, Pillarisetty R, Papoian R, Roubinian J Experimental lupus: a disorder of immunologic regulation. Adv Nephrol Necker Hosp. 1976 ;6():37-45. PMID: 828451 [PubMed - indexed for MEDLINE]