Marcia A. Kaetzel, PhD
Res. Assoc. Prof.
Department of Molecular Oncogenesis ML 0505
University of Cincinnati
Genome Research Institute
2180 E. Galbraith Rd.
Cincinnati, Ohio 45237

Email Marcia

Publications

Publications

1:	Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron. 2006 Oct;52(2):321-33. PMID: 17046694 [PubMed - indexed for MEDLINE]

2:	Folkerts MM, Parks EA, Dedman JR, Kaetzel MA, Lyeth BG, Berman RF Phosphorylation of calcium calmodulin-dependent protein kinase II following lateral fluid percussion brain injury in rats. J Neurotrauma. 2007 Apr;24(4):638-50. PMID: 17439347 [PubMed - indexed for MEDLINE]

3:	Li B, Dedman JR, Kaetzel MA Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart. Biochim Biophys Acta. 2006 Nov;1763(11):1275-81. PMID: 17069901 [PubMed - indexed for MEDLINE]

4:	Picht E, DeSantiago J, Huke S, Kaetzel MA, Dedman JR, Bers DM CaMKII inhibition targeted to the sarcoplasmic reticulum inhibits frequency-dependent acceleration of relaxation and Ca2+ current facilitation. J Mol Cell Cardiol. 2007 Jan;42(1):196-205. PMID: 17052727 [PubMed - indexed for MEDLINE]

5:	Li B, Kaetzel MA, Dedman JR Signaling pathways regulating murine cardiac CREB phosphorylation. Biochem Biophys Res Commun. 2006 Nov;350(1):179-84. PMID: 16996475 [PubMed - indexed for MEDLINE]

6:

Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers DM, Dedman JR Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility. Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H599-606. PMID: 16143658 [PubMed - indexed for MEDLINE]

7:	Kaetzel MA, Dedman JR Annexin VI regulation of cardiac function. Biochem Biophys Res Commun. 2004 Oct;322(4):1171-7. PMID: 15336965 [PubMed - indexed for MEDLINE]

8:	Robinson NC, Huang P, Kaetzel MA, Lamb FS, Nelson DJ Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current. J Physiol. 2004 Apr;556(Pt 2):353-68. PMID: 14754994 [PubMed - indexed for MEDLINE]

9:	Beauman SR, Campos B, Kaetzel MA, Dedman JR CyclinB1 expression is elevated and mitosis is delayed in HeLa cells expressing autonomous CaMKII. Cell Signal. 2003 Nov;15(11):1049-57. PMID: 14499348 [PubMed - indexed for MEDLINE]

10:	Li B, Dedman JR, Kaetzel MA Intron disruption of the annexin IV gene reveals novel transcripts. J Biol Chem. 2003 Oct;278(44):43276-83. PMID: 12912993 [PubMed - indexed for MEDLINE]

11:	Dvornikovs V, House BE, Kaetzel M, Dedman JR, Smithrud DB Host-[2]rotaxanes as cellular transport agents. J Am Chem Soc. 2003 Jul;125(27):8290-301. PMID: 12837101 [PubMed - indexed for MEDLINE]

12:	Hill WG, Kaetzel MA, Kishore BK, Dedman JR, Zeidel ML Annexin A4 reduces water and proton permeability of model membranes but does not alter aquaporin 2-mediated water transport in isolated endosomes. J Gen Physiol. 2003 May;121(5):413-25. PMID: 12695484 [PubMed - indexed for MEDLINE]

13:

Ji Y, Li B, Reed TD, Lorenz JN, Kaetzel MA, Dedman JR Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17. J Biol Chem. 2003 Jul;278(27):25063-71. PMID: 12692124 [PubMed - indexed for MEDLINE]

14:	Kutcher LW, Beauman SR, Gruenstein EI, Kaetzel MA, Dedman JR Nuclear CaMKII inhibits neuronal differentiation of PC12 cells without affecting MAPK or CREB activation. Am J Physiol Cell Physiol. 2003 Jun;284(6):C1334-45. PMID: 12570987 [PubMed - indexed for MEDLINE]

15:	Wang X, Kaetzel MA, Yoo SE, Kim PS, Dedman JR Ligand-regulated secretion of recombinant annexin V from cultured thyroid epithelial cells. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1313-21. PMID: 11997246 [PubMed - indexed for MEDLINE]

16:	Wang X, Campos B, Kaetzel MA, Dedman JR Secretion of annexin V from cultured cells requires a signal peptide. Placenta. 2001 Nov;22(10):837-45. PMID: 11718571 [PubMed - indexed for MEDLINE]

17:	Kaetzel MA, Mo YD, Mealy TR, Campos B, Bergsma-Schutter W, Brisson A, Dedman JR, Seaton BA Phosphorylation mutants elucidate the mechanism of annexin IV-mediated membrane aggregation. Biochemistry. 2001 Apr;40(13):4192-9. PMID: 11300800 [PubMed - indexed for MEDLINE]

18:

Ho MW, Kaetzel MA, Armstrong DL, Shears SB Regulation of a human chloride channel. a paradigm for integrating input from calcium, type ii calmodulin-dependent protein kinase, and inositol 3,4,5,6-tetrakisphosphate. J Biol Chem. 2001 Jun;276(22):18673-80. PMID: 11279175 [PubMed - indexed for MEDLINE]

19:	Huang P, Liu J, Di A, Robinson NC, Musch MW, Kaetzel MA, Nelson DJ Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase. J Biol Chem. 2001 Jun;276(23):20093-100. PMID: 11274166 [PubMed - indexed for MEDLINE]

20:	Gotter AL, Kaetzel MA, Dedman JR Electrophorus electricus as a model system for the study of membrane excitability. Comp Biochem Physiol A Mol Integr Physiol. 1998 Jan;119(1):225-41. PMID: 11253789 [PubMed - indexed for MEDLINE]

21:	Campos B, Wang S, Retzinger GS, Kaetzel MA, Seaton BA, Karin NJ, Johnson JD, Dedman JR Mutation of highly conserved arginine residues disrupts the structure and function of annexin V. Arch Med Res. ;30(5):360-7. PMID: 10596454 [PubMed - indexed for MEDLINE]

22:	Aguilar L, Ortega-Pierres G, Campos B, Fonseca R, Ibáñez M, Wong C, Farfán N, Naciff JM, Kaetzel MA, Dedman JR, Baeza I Phospholipid membranes form specific nonbilayer molecular arrangements that are antigenic. J Biol Chem. 1999 Sep;274(36):25193-6. PMID: 10464237 [PubMed - indexed for MEDLINE]

23:	Wang X, Campos B, Kaetzel MA, Dedman JR Annexin V is critical in the maintenance of murine placental integrity. Am J Obstet Gynecol. 1999 Apr;180(4):1008-16. PMID: 10203671 [PubMed - indexed for MEDLINE]

24:	King KL, Moreira KM, Babcock GF, Wang J, Campos B, Kaetzel MA, Dedman JR Temporal inhibition of calmodulin in the nucleus. Biochim Biophys Acta. 1998 Dec;1448(2):245-53. PMID: 9920415 [PubMed - indexed for MEDLINE]

25:

Xie W, Solomons KR, Freeman S, Kaetzel MA, Bruzik KS, Nelson DJ, Shears SB Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatases. J Physiol. 1998 Aug;510 ( Pt 3)():661-73. PMID: 9660883 [PubMed - indexed for MEDLINE]

26:	Gotter AL, Kaetzel MA, Dedman JR A major second messenger mediator of Electrophorus electricus electric tissue is CaM kinase II. Comp Biochem Physiol A Physiol. 1997 Sep;118(1):81-91. PMID: 9243814 [PubMed - indexed for MEDLINE]

27:	Naciff JM, Behbehani MM, Kaetzel MA, Dedman JR Annexin VI modulates Ca2+ and K+ conductances of spinal cord and dorsal root ganglion neurons. Am J Physiol. 1996 Dec;271(6 Pt 1):C2004-15. PMID: 8997203 [PubMed - indexed for MEDLINE]

28:	Wang J, Moreira KM, Campos B, Kaetzel MA, Dedman JR Targeted neutralization of calmodulin in the nucleus blocks DNA synthesis and cell cycle progression. Biochim Biophys Acta. 1996 Oct;1313(3):223-8. PMID: 8898858 [PubMed - indexed for MEDLINE]

29:	Wang J, Campos B, Kaetzel MA, Dedman JR Expression of a calmodulin inhibitor peptide in progenitor alveolar type II cells disrupts lung development. Am J Physiol. 1996 Aug;271(2 Pt 1):L245-50. PMID: 8770063 [PubMed - indexed for MEDLINE]

30:	Xie W, Kaetzel MA, Bruzik KS, Dedman JR, Shears SB, Nelson DJ Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. J Biol Chem. 1996 Jun;271(24):14092-7. PMID: 8662902 [PubMed - indexed for MEDLINE]

31:	Naciff JM, Kaetzel MA, Behbehani MM, Dedman JR Differential expression of annexins I-VI in the rat dorsal root ganglia and spinal cord. J Comp Neurol. 1996 May;368(3):356-70. PMID: 8725344 [PubMed - indexed for MEDLINE]

32:	Gunteski-Hamblin AM, Song G, Walsh RA, Frenzke M, Boivin GP, Dorn GW, Kaetzel MA, Horseman ND, Dedman JR Annexin VI overexpression targeted to heart alters cardiomyocyte function in transgenic mice. Am J Physiol. 1996 Mar;270(3 Pt 2):H1091-100. PMID: 8780208 [PubMed - indexed for MEDLINE]

33:	Ismailov II, Awayda MS, Jovov B, Berdiev BK, Fuller CM, Dedman JR, Kaetzel M, Benos DJ Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 1996 Mar;271(9):4725-32. PMID: 8617738 [PubMed - indexed for MEDLINE]

34:	Nelson DJ, Tien XY, Xie W, Brasitus TA, Kaetzel MA, Dedman JR Shrinkage activates a nonselective conductance: involvement of a Walker-motif protein and PKC. Am J Physiol. 1996 Jan;270(1 Pt 1):C179-91. PMID: 8772443 [PubMed - indexed for MEDLINE]

35:	Wang J, Campos B, Jamieson GA, Kaetzel MA, Dedman JR Functional elimination of calmodulin within the nucleus by targeted expression of an inhibitor peptide. J Biol Chem. 1995 Dec;270(51):30245-8. PMID: 8530438 [PubMed - indexed for MEDLINE]

36:	Jovov B, Ismailov II, Berdiev BK, Fuller CM, Sorscher EJ, Dedman JR, Kaetzel MA, Benos DJ Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels. J Biol Chem. 1995 Dec;270(49):29194-200. PMID: 7493947 [PubMed - indexed for MEDLINE]

37:	Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V. Nat Struct Biol. 1995 Nov;2(11):968-74. PMID: 7583670 [PubMed - indexed for MEDLINE]

38:	Chan HC, Kaetzel MA, Gotter AL, Dedman JR, Nelson DJ Annexin IV inhibits calmodulin-dependent protein kinase II-activated chloride conductance. A novel mechanism for ion channel regulation. J Biol Chem. 1994 Dec;269(51):32464-8. PMID: 7798247 [PubMed - indexed for MEDLINE]

39:	Kaetzel MA, Pula G, Campos B, Uhrin P, Horseman N, Dedman JR Annexin VI isoforms are differentially expressed in mammalian tissues. Biochim Biophys Acta. 1994 Sep;1223(3):368-74. PMID: 7918672 [PubMed - indexed for MEDLINE]

40:	Kaetzel MA, Chan HC, Dubinsky WP, Dedman JR, Nelson DJ A role for annexin IV in epithelial cell function. Inhibition of calcium-activated chloride conductance. J Biol Chem. 1994 Feb;269(7):5297-302. PMID: 8106514 [PubMed - indexed for MEDLINE]

41:	Tien XY, Brasitus TA, Kaetzel MA, Dedman JR, Nelson DJ Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2. J Biol Chem. 1994 Jan;269(1):51-4. PMID: 7506258 [PubMed - indexed for MEDLINE]

42:	Dedman JR, Kaetzel MA, Chan HC, Nelson DJ, Jamieson GA Selection of targeted biological modifiers from a bacteriophage library of random peptides. The identification of novel calmodulin regulatory peptides. J Biol Chem. 1993 Nov;268(31):23025-30. PMID: 8226817 [PubMed - indexed for MEDLINE]

43:	Raju U, Nunez-Regueiro M, Cook R, Kaetzel MA, Yeung SC, Eskin A Identification of an annexin-like protein and its possible role in the Aplysia eye circadian system. J Neurochem. 1993 Oct;61(4):1236-45. PMID: 8376982 [PubMed - indexed for MEDLINE]

44:	Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA Rat annexin V crystal structure: Ca(2+)-induced conformational changes. Science. 1993 Sep;261(5126):1321-4. PMID: 8362244 [PubMed - indexed for MEDLINE]

45:	Cuppoletti J, Huang P, Kaetzel MA, Malinowska DH Stimulus-associated protein in gastric parietal cell detected using antimelittin antibody. Am J Physiol. 1993 Apr;264(4 Pt 1):G637-44. PMID: 8386462 [PubMed - indexed for MEDLINE]

46:	Yeatman TJ, Updyke TV, Kaetzel MA, Dedman JR, Nicolson GL Expression of annexins on the surfaces of non-metastatic and metastatic human and rodent tumor cells. Clin Exp Metastasis. 1993 Jan;11(1):37-44. PMID: 8422704 [PubMed - indexed for MEDLINE]

47:	Concha NO, Head JF, Kaetzel MA, Dedman JR, Seaton BA Annexin V forms calcium-dependent trimeric units on phospholipid vesicles. FEBS Lett. 1992 Dec;314(2):159-62. PMID: 1459245 [PubMed - indexed for MEDLINE]

48:	Chan HC, Kaetzel MA, Nelson DJ, Hazarika P, Dedman JR Antibody against a cystic fibrosis transmembrane conductance regulator-derived synthetic peptide inhibits anion currents in human colonic cell line T84. J Biol Chem. 1992 Apr;267(12):8411-6. PMID: 1373728 [PubMed - indexed for MEDLINE]

49:	Raab LS, Decker GL, Jonas AJ, Kaetzel MA, Dedman JR Glucocorticoid regulation of rat liver urate oxidase. J Cell Biochem. 1991 Sep;47(1):18-30. PMID: 1939364 [PubMed - indexed for MEDLINE]

50:	Feinberg JM, Rainteau DP, Kaetzel MA, Dacheux JL, Dedman JR, Weinman SJ Differential localization of annexins in ram germ cells: a biochemical and immunocytochemical study. J Histochem Cytochem. 1991 Jul;39(7):955-63. PMID: 1830893 [PubMed - indexed for MEDLINE]

51:	Hazarika P, Kaetzel MA, Sheldon A, Karin NJ, Fleischer S, Nelson TE, Dedman JR Annexin VI is associated with calcium-sequestering organelles. J Cell Biochem. 1991 May;46(1):78-85. PMID: 1831459 [PubMed - indexed for MEDLINE]

52:	Hazarika P, Sheldon A, Kaetzel MA, Díaz-Muñoz M, Hamilton SL, Dedman JR Regulation of the sarcoplasmic reticulum Ca(2+)-release channel requires intact annexin VI. J Cell Biochem. 1991 May;46(1):86-93. PMID: 1651943 [PubMed - indexed for MEDLINE]

53:	Goldberg M, Feinberg J, Lecolle S, Kaetzel MA, Rainteau D, Lessard JL, Dedman JR, Weinman S Co-distribution of annexin VI and actin in secretory ameloblasts and odontoblasts of rat incisor. Cell Tissue Res. 1991 Jan;263(1):81-9. PMID: 1826233 [PubMed - indexed for MEDLINE]

54:	Goldberg M, Feinberg J, Rainteau D, Lecolle S, Kaetzel MA, Dedman JR, Weinman S Annexins I-VI in secretory ameloblasts and odontoblasts of rat incisor. J Biol Buccale. 1990 Dec;18(4):289-98. PMID: 2151331 [PubMed - indexed for MEDLINE]

55:	Kaetzel MA, Hazarika P, Diaz-Munoz M, Dubinsky W, Hamilton SL, Dedman JR Annexins: a subcellular localization and reconstitution approach to elucidate cellular function. Biochem Soc Trans. 1990 Dec;18(6):1108-10. PMID: 2150942 [PubMed - indexed for MEDLINE]

56:	Díaz-Muñoz M, Hamilton SL, Kaetzel MA, Hazarika P, Dedman JR Modulation of Ca2+ release channel activity from sarcoplasmic reticulum by annexin VI (67-kDa calcimedin). J Biol Chem. 1990 Sep;265(26):15894-9. PMID: 2168425 [PubMed - indexed for MEDLINE]

57:	Seaton BA, Head JF, Kaetzel MA, Dedman JR Purification, crystallization, and preliminary X-ray diffraction analysis of rat kidney annexin V, a calcium-dependent phospholipid-binding protein. J Biol Chem. 1990 Mar;265(8):4567-9. PMID: 2307675 [PubMed - indexed for MEDLINE]

58:	Smith VL, Kaetzel MA, Dedman JR Stimulus-response coupling: the search for intracellular calcium mediator proteins. Cell Regul. 1990 Jan;1(2):165-72. PMID: 2100195 [PubMed - indexed for MEDLINE]

59:	Kaetzel MA, Hazarika P, Dedman JR Differential tissue expression of three 35-kDa annexin calcium-dependent phospholipid-binding proteins. J Biol Chem. 1989 Aug;264(24):14463-70. PMID: 2527237 [PubMed - indexed for MEDLINE]

60:	Kaetzel MA, Dedman JR Affinity-purified site-directed antibody recognizes the entire annexin protein family. Biochem Biophys Res Commun. 1989 May;160(3):1233-7. PMID: 2471519 [PubMed - indexed for MEDLINE]

61:	Rainteau DP, Weinman SJ, Kabaktchis CA, Smith VL, Kaetzel MA, Dedman JR, Weinman JS The expression of the 35- and 67-kDa calcimedins is dependent on thyroid hormone. J Biol Chem. 1988 Sep;263(26):12844-8. PMID: 2971036 [PubMed - indexed for MEDLINE]

62:	Kaetzel MA, Dedman JR Affinity-purified melittin antibody recognizes the calmodulin-binding domain on calmodulin target proteins. J Biol Chem. 1987 Mar;262(8):3726-9. PMID: 3818662 [PubMed - indexed for MEDLINE]

63:	Kaetzel MA, Dedman JR Identification of a 55-kDa high-affinity calmodulin-binding protein from Electrophorus electricus. J Biol Chem. 1987 Feb;262(4):1818-22. PMID: 3543014 [PubMed - indexed for MEDLINE]

64:	Dedman JR, Kaetzel MA Calmodulin purification and fluorescent labeling. Methods Enzymol. 1983 ;102():1-8. PMID: 6645966 [PubMed - indexed for MEDLINE]

65:	Kaetzel M, Pardue R, Brinkley BR, Dedman J Fluorescently-labeled calmodoulin localizes specific sites on mitochondria. Ann N Y Acad Sci. 1980 ;356():395-6. PMID: 7015960 [PubMed - indexed for MEDLINE]

66:	Pardue RL, Kaetzel MA, Hahn SH, Brinkley BR, Dedman JR The identification of calmodulin-binding sites on mitochondria in cultured 3T3 cells. Cell. 1981 Feb;23(2):533-42. PMID: 7193532 [PubMed - indexed for MEDLINE]