Randy J. Seeley, Ph.D.
Professor of Psychiatry
Genome Research Institute
Building E, 3rd Floor
2170 E. Galbraith Rd
Cincinnati, OH 45237


Email Randy

Honors
Funding
Publications

Dr. Randy Seeley is Professor of Psychiatry and Associate Director of the Obesity Research Center at the University of Cincinnati College of Medicine. His work has focused on the actions of various peripheral hormones in the CNS that serve to regulate food intake and body weight. In particular, he has focused upon the numerous hypothalamic and G.I. peptides and their associated receptors that influence both energy intake and energy expenditure.


Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before locating to the University of Cincinnati in 1997. He has published over 150 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience Reviews, The Journal of Clincial Investigation and the New England Journal of Medicine. He is also the author of 12 book chapters and co-edited a volume on macronutrient selection. He also is the recipient of the 2003 Lilly Scientific Achievement award from the North American Association for the Study of Obesity given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree.



Honors:
Early Career Award from Society for the Study of Ingestive Behavior (2001)
Award for the highest scientific achievement of an individual studying ingestive behavior less than 10 years after their terminal degree.

Lilly Scientific Achievement Award from North American Association for the Study of Obesity (2003). Award for highest scientific achievement in obesity related research in North America by an individual no more than 15 years after their terminal degree.

Gayle A. and Richard D. Olson Prize (2005). Award for best paper published in Peptides.

Sigma Xi Research Award (2006)

Award for the highest research achievement at the University of Cincinnati for an individual less than 15 years since their terminal degree.


Funding Support
Body Fat and Hormones in Adolescent Obesity Treatment. (2002-2007) Mentor for Brian Saelens. K08-Mentored patient-oriented research career development award (Total DC: $414,990).

Exploring Barriers to Treatment: Pediatric Obesity. (2002-2007) Mentor for Meg Zeller K08-Mentored patient-oriented research career development award (Total DC: $416,018)

Regulatory responses to positive energy balance. (2002-2007) PI, R01 Award, NIDDK, $860,640 (DC).

Brainstem Mechanisms of Stress Regulation. (2003-2008) Co-Investigator, R01 (PI: James Herman). $1,125,000 (DC).

Mechanisms of ileal-induced weight loss (2003-2006). Mentor, 3-year NRSA Award for Dr. A.D. Strader, $136,176 (DC).

GLP-1 and stress-induced body weight regulation (2004-2006). Mentor, 3-year NRSA Award for Dr. J.B. Chambers, ~$140,000 (DC).

Central Syndecans in CNS Melanocortin Regulation of Energy Balance. (2004-2008). Co-Investigator, R01 (PI: Stephen Benoit) $800,000 (DC).

The Role of Glucagon-like Peptide 1 in Normal and Abnormal Glucose Tolerance. (2004-2009). Co-Investigator, R01 (PI: David D’Alessio) $1,000,000

Il-1-dependent anorexia during CNS viral infection (2005-2007). Co-Investigator, R21 (PI: David Hildeman) $375,000 (DC).

Sexual dimorphism in body-fat regulation (2006-2009). Mentor, 3-year NRSA award for Dr. Haifei Shi, ~$140,000 (DC).

Screening of obesity compounds (2006). Predix Pharmaceuticals, $30,000.

Molecular connections between arousal and metabolic disease: Orexin and modafinil (2006-2010). PI for project 2, 4 year award from USARMC. $620,264 (DC for just Project 2).

CNS processes in diet-induced obesity. (2006-2011) PI, 5-year R01 award, submitted as part of a Program Project Proposal to NIDDK titled “Gut-Brain Mechanisms of Dietary Obesity” (PI: SC Woods), $800,000 (DC).

GM-CSF and energy and glucose regulation. (2006-2011) PI, 5 year R01 award received an 8.0%, $1,250,000 (DC).

Differential effects of dietary fats on CNS regulation of energy balance. (2006-2009) Mentor for American Diabetes Association Physician-Scientist Training Award to Jason Barrera. $90,000 (DC).

Novel Role for CNS GLP-1 in Glucose Homeostasis (2006-2011). Mentor for K01-Award to Dr. Darleen Sandoval. $615,248 (DC).



Publications

1:	Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ Hypothalamic mTOR signaling regulates food intake. Science. 2006 May;312(5775):927-30. PMID: 16690869 [PubMed - indexed for MEDLINE]

2:	Cota D, Barrera JG, Seeley RJ Leptin in energy balance and reward: two faces of the same coin? Neuron. 2006 Sep;51(6):678-80. PMID: 16982412 [PubMed - indexed for MEDLINE]

3:	Seeley RJ, Tschöp M How diabetes went to our heads. Nat Med. 2006 Jan;12(1):47-9; discussion 49. PMID: 16397565 [PubMed - indexed for MEDLINE]

4:	Seeley RJ More neurons, less weight. Nat Med. 2005 Dec;11(12):1276-8. PMID: 16333262 [PubMed - indexed for MEDLINE]

5:	D'Alessio DA, Sandoval DA, Seeley RJ New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest. 2005 Dec;115(12):3406-8. PMID: 16322789 [PubMed - indexed for MEDLINE]

6:	Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ GM-CSF action in the CNS decreases food intake and body weight. J Clin Invest. 2005 Nov;115(11):3035-44. PMID: 16276414 [PubMed - indexed for MEDLINE]

7:	Strader AD, Reizes O, Woods SC, Benoit SC, Seeley RJ Mice lacking the syndecan-3 gene are resistant to diet-induced obesity. J Clin Invest. 2004 Nov;114(9):1354-60. PMID: 15520868 [PubMed - indexed for MEDLINE]