Genome Research Institute
University of Cincinnati
2180 E. Galbraith Road
Cincinnati, Ohio 45237

Email Sandra

Honors
Publications

Sandra Nelson is responsible for the High-Throughput Screening (HTS) and Assay Development Lab. Assay development and HTS services are provided as part of the Drug Discovery Core. Biochemical and cell-based assays can be used to screen the University of Cincinnati’s Compound Library, or compounds supplied by the service user. Sandra considers herself an analytical biochemist and provides consulting on assay development, HTS assay methods utilizing sophisticated chemistry for homogeneous assays, follow-up screening, designing assay screening tiers, laboratory automation, and use of database and HTS software tools.

Before joining GRI in September 2006, Sandra was responsible for the HTS and Compound Repository facility for P&G Pharmaceuticals. During her 18 year career with P&G, she also performed research to develop new over-the-counter products for P&G (toothpaste, mouthwash, cough & cold medicines, gastrointestinal medicine), and developed and ran biochemical assays, including those for clinical studies, helping to develop new pharmaceutical products. Sandra worked at the USDA National Animal Disease Center studying diseases of agricultural animals, and at the USDOE Ames Laboratory developing new measurement methods for environmental carcinogens and possible biological hazards. She received a Ph.D. in biochemistry from the University of North Carolina at Chapel Hill, and a B.S. in biochemistry from Iowa State University.



Honors:
Scientific Activities
2006 - present Board of Directors for the Society for Biomolecular Screening
2003 – present editorial board member for the Journal of Biomolecular Screening
2000 - 2003 reviewer for the Journal of Biomolecular Screening

2005 reviewer for Drug Discovery

2001 – 2005 member Molecular Biotechnology HTS Graduate Program Oversight Committee at Western Michigan University

2003 Organized first Midwest Chapter Laboratory Robotics Information Group (LRIG) meeting in Cincinnati

April 10 - 12, 2000 member of Special Emphasis Panel to review 12 grant applications in response to RFA 99-010, “National Cooperative Drug Discovery Groups” for the National Cancer Institute



Publications

1:	Walters SN, Morell P Effects of altered thyroid states on myelinogenesis. J Neurochem. 1981 May;36(5):1792-801. PMID: 7241137 [PubMed - indexed for MEDLINE]

2:	Walters SN, D'Silva AP, Fassel VA Immobilized enzyme system for the conversion of benzo[a]pyrene to fluorescent metabolites. Anal Chem. 1982 Dec;54(14):2571-6. PMID: 6297334 [PubMed - indexed for MEDLINE]

3:	Walters SN, Reinhardt TA, Dominick MA, Horst RL, Littledike ET Intracellular location of unoccupied 1,25-dihydroxyvitamin D receptors: a nuclear-cytoplasmic equilibrium. Arch Biochem Biophys. 1986 Apr;246(1):366-73. PMID: 3008657 [PubMed - indexed for MEDLINE]

4:	Nelson SL, Frank GH Bovine serum and nasal secretion immunoglobulins against Pasteurella haemolytica serotype 1 antigens. Am J Vet Res. 1989 Aug;50(8):1244-9. PMID: 2782707 [PubMed - indexed for MEDLINE]

5:	Nelson SL, Frank GH Purification and characterization of a 94-kDa Pasteurella haemolytica antigen. Vet Microbiol. 1989 Nov;21(1):57-66. PMID: 2623797 [PubMed - indexed for MEDLINE]

6:	Frank GH, Nelson SL, Briggs RE Infection of the middle nasal meatus of calves with Pasteurella haemolytica serotype 1. Am J Vet Res. 1989 Aug;50(8):1297-301. PMID: 2551200 [PubMed - indexed for MEDLINE]

7:	Nelson SL, Hynd BA, Pickrum HM Automated enzyme immunoassay to measure prostaglandin E2 in gingival crevicular fluid. J Periodontal Res. 1992 Mar;27(2):143-8. PMID: 1532203 [PubMed - indexed for MEDLINE]

8:	Nelson SL, Hynd BA ELISA kits measuring human IgG subclasses: cross-reactivity against IgG3 in an IgG1 ELISA. Clin Chem. 1993 Sep;39(9):1919. PMID: 8375073 [PubMed - indexed for MEDLINE]

9:

Jeffcoat MK, Reddy MS, Haigh S, Buchanan W, Doyle MJ, Meredith MP, Nelson SL, Goodale MB, Wehmeyer KR A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol. 1995 May;66(5):329-38. PMID: 7623251 [PubMed - indexed for MEDLINE]

10:	Nelson SL, Sanregret JD Response of pigs to bitter-tasting compounds. Chem Senses. 1997 Apr;22(2):129-32. PMID: 9146902 [PubMed - indexed for MEDLINE]

11:	Davis GF, Downs TR, Farmer JA, Pierson CR, Roesgen JT, Cabrera EJ, Nelson SL Comparison of high throughput screening technologies for luminescence cell-based reporter screens. J Biomol Screen. 2002 Feb;7(1):67-77. PMID: 11897057 [PubMed - indexed for MEDLINE]

12:

Roychoudhury S, Makin KM, Twinem TL, Stanton DT, Nelson SL, Catrenich CE Development and use of a high-throughput bacterial DNA gyrase assay to identify mammalian topoisomerase II inhibitors with whole-cell anticancer activity. J Biomol Screen. 2003 Apr;8(2):157-63. PMID: 12844436 [PubMed - indexed for MEDLINE]

13:	Kozikowski BA, Burt TM, Tirey DA, Williams LE, Kuzmak BR, Stanton DT, Morand KL, Nelson SL The effect of room-temperature storage on the stability of compounds in DMSO. J Biomol Screen. 2003 Apr;8(2):205-9. PMID: 12844442 [PubMed - indexed for MEDLINE]

14:	Kozikowski BA, Burt TM, Tirey DA, Williams LE, Kuzmak BR, Stanton DT, Morand KL, Nelson SL The effect of freeze/thaw cycles on the stability of compounds in DMSO. J Biomol Screen. 2003 Apr;8(2):210-5. PMID: 12844443 [PubMed - indexed for MEDLINE]